diff --git a/src/google/protobuf/descriptor.cc b/src/google/protobuf/descriptor.cc
index 7456d3c3d6653..7731a9405e031 100644
--- a/src/google/protobuf/descriptor.cc
+++ b/src/google/protobuf/descriptor.cc
@@ -343,22 +343,16 @@ class FlatAllocation {
     return ends_.template Get<U>();
   }
 
-  // Avoid the reinterpret_cast if the array is empty.
-  // Clang's Control Flow Integrity does not like the cast pointing to memory
-  // that is not yet initialized to be of that type.
-  // (from -fsanitize=cfi-unrelated-cast)
   template <typename U>
+  PROTOBUF_NO_SANITIZE("cfi-unrelated-cast", "vptr")
   U* Begin() const {
-    int begin = BeginOffset<U>(), end = EndOffset<U>();
-    if (begin == end) return nullptr;
-    return reinterpret_cast<U*>(data() + begin);
+    return reinterpret_cast<U*>(data() + BeginOffset<U>());
   }
 
   template <typename U>
+  PROTOBUF_NO_SANITIZE("cfi-unrelated-cast", "vptr")
   U* End() const {
-    int begin = BeginOffset<U>(), end = EndOffset<U>();
-    if (begin == end) return nullptr;
-    return reinterpret_cast<U*>(data() + end);
+    return reinterpret_cast<U*>(data() + EndOffset<U>());
   }
 
   template <typename U>
diff --git a/src/google/protobuf/map.h b/src/google/protobuf/map.h
index 71abcb9b80564..2d3ef18139e2f 100644
--- a/src/google/protobuf/map.h
+++ b/src/google/protobuf/map.h
@@ -320,6 +320,7 @@ class PROTOBUF_EXPORT UntypedMapBase {
   UntypedMapBase& operator=(const UntypedMapBase&) = delete;
 
   template <typename T>
+  PROTOBUF_NO_SANITIZE("cfi-unrelated-cast", "vptr")
   T* GetKey(NodeBase* node) const {
     // Debug check that `T` matches what we expect from the type info.
     ABSL_DCHECK_EQ(static_cast<int>(StaticTypeKind<T>()),
@@ -332,6 +333,7 @@ class PROTOBUF_EXPORT UntypedMapBase {
   }
 
   template <typename T>
+  PROTOBUF_NO_SANITIZE("cfi-unrelated-cast", "vptr")
   T* GetValue(NodeBase* node) const {
     // Debug check that `T` matches what we expect from the type info.
     ABSL_DCHECK_EQ(static_cast<int>(StaticTypeKind<T>()),
diff --git a/src/google/protobuf/port_def.inc b/src/google/protobuf/port_def.inc
index a12a49e9971af..8b2ebe31195d2 100644
--- a/src/google/protobuf/port_def.inc
+++ b/src/google/protobuf/port_def.inc
@@ -601,6 +601,16 @@ static_assert(PROTOBUF_ABSL_MIN(20230125, 3),
 #define PROTOBUF_PREFETCH_WITH_OFFSET(base, offset)
 #endif
 
+#if !defined(_MSVC_LANG)
+#if __has_attribute(no_sanitize)
+#define PROTOBUF_NO_SANITIZE(...) __attribute__((no_sanitize(__VA_ARGS__)))
+#else
+#define PROTOBUF_NO_SANITIZE(...)
+#endif  // __has_attribute(no_sanitize)
+#else
+#define PROTOBUF_NO_SANITIZE(...)
+#endif
+
 // ThreadSafeArenaz is turned off completely in opensource builds.